Learning and Memory Deficits After Ibotenate Lesions of the Nucleus Basalis: Reversal by Cholinomimetics
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چکیده
منابع مشابه
Effects of exercise on spatial memory deficits induced by nucleus basalis magnocellularis lesions
Introduction: Previous studies have shown that exercise enhances cognitive and functional capacities in patients with Alzheimer's disease (AD). In this study, we investigated the effect of long-term (60 days) and short- term (10 days) exercise on the spatial memory deficits in an animal model of AD. Methods: Fifty male rats were divided into 5 groups 1) intact, 2) sham, 3) sham-Alzheimer 4) ...
متن کاملEffects of exercise on spatial memory deficits induced by nucleus basalis magnocellularis lesions
Introduction: Previous studies have shown that exercise enhances cognitive and functional capacities in patients with Alzheimer's disease (AD). In this study, we investigated the effect of long-term (60 days) and shortterm (10 days) exercise on the spatial memory deficits in an animal model of AD. Methods: Fifty male rats were divided into 5 groups; 1) intact, 2) sham, 3) sham-Alzheimer 4) Alzh...
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Specific behavioral associative memory induced by stimulation of the cortically-projecting cholinergic nucleus basalis (NB) is dependent on intrinsic acetylcholine and shares with natural memory such features as associativity, specificity, rapid formation, consolidation and long-term retention. Herein, we examined extinction and the effects of stimulus pre-exposure. Two groups of adult male rat...
متن کاملLesions in nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments.
The functional contribution of nucleus basalis magnocellularis (NBM) and the medial septal area (MSA) to memory was evaluated in two different spatial discriminations. Preoperatively, rats were trained to a criterion level of performance in a simultaneous left/right discrimination on the stem of a T-maze (a trial-independent memory) and a discrete-trial, rewarded alternation discrimination on t...
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Functional dissociations between the medial septal area (MSA) and the nucleus basalis magnocellularis (NBM) were examined using the concepts and experimental procedures developed by scalar timing theory. Rats were tested in variations of a signalled discrete-trial peak-interval schedule of reinforcement in which the response rate functions identified the time when the rats expected reinforcemen...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 1986
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100037197